Research Department Nutrition and Food Sciences

Gregor-Mendel-Str. 2
85350 Freising

Tel.: 08161/ 71 - 2026
Fax: 08161/ 71 - 2824


Selected Publications




Rubio-Aliaga I, Daniel H. Peptide transporters and their roles in physiological processes and drug disposition. Xenobiotica. 2008 Jul;38(7-8):1022-42 Pubmed

Kussmann M, Rezzi S, Daniel H. Profiling techniques in nutrition and health research. Curr Opin Biotechnol. 2008 Apr;19(2):83-99 Pubmed

Fuchs D, Piller R, Linseisen J, Daniel H, Wenzel U. The human peripheral blood mononuclear cell proteome responds to a dietary flaxseed-intervention and proteins identified suggest a protective effect in atherosclerosis. Proteomics. 2007 Sep;7(18):3278-88 Pubmed

Kottra G, Daniel H. Flavonoid-glycosides are not transported by the human Na+/glucose transporter when expressed in Xenopus leavis oocytes, but effectively inhibit electrogenic glucose uptake.J Pharmacol Exp Ther. 2007 Aug;322(2):829-35 Pubmed

Winkelmann I, Diehl D, Oesterle D, Daniel H, Wenzel U. The suppression of aberrant crypt multiplicity in colonic tissue of 1,2-dimethylhydrazine-treated C57BL/6J mice by dietary flavone is associated with an increased expression of Krebs-cycle enzymes. Carcinogenesis. 2007 Jul;28(7):1446-54 Pubmed




Shu XL, Frank T, Shu QY, Engel KH. Metabolite profiling of germinating rice seeds. J. Agric Food Chem 56: 11612-20, 2008 Pubmed

Frank T, Seumo Meuleye B, Miller A, Shu QS, Engel KH. Metabolite profiling of two low phytic acid (lpa) rice mutants. J. Agric Food Chem 55:10339-44, 2007 Pubmed

Strohalm H, Dreagus M, Wahl A, Engel KH. Enantioselective analysis of secondary alcohols and their esters in purple and yellow passion fruits. J Agric Food Chem 55, 10339-44, 2007 Pubmed

Takahisa E, Engel KH. 2,3-Di-O-methoxymethyl-6-O-tert-butyldimethylsilyl-γ-cyclodextrin: a new class of cyclodextrin derivatives for gas chromatographic separation of enanatiomers. J. Chromatogr A 1063: 181-92, 2005 Pubmed

Demmel A, Hupfer C, Ilg Hampe E, Busch U, Engel KH. Development of a real-time PCR for the detection of lupine DNA (Lupinus species) in foods. J Agric Food Chem 56: 4328-32, 2008 Pubmed




Martin FP, Rezzi S, Philippe D, Tornier L, Messlik A, Hölzlwimmer G, Baur P, Quintanilla-Fend L, Loh G, Blaut M, Blum S, Kochhar S, Haller D. Metabolic Assessment of Gradual Development of Moderate Experimental Colitis in IL-10 Deficient Mice. J. Proteome Res. 1;8(5):2376-2387, 2009 Pubmed

Hörmannsperger G, Clavel T, Hoffmann M, Reiff C, Kelly D, Loh G, Blaut M, Hölzlwimmer G, Laschinger M, Haller D. Post-translational inhibition of IP-10 secretion in IEC by probiotic bacteria: Impact on chronic inflammation. PLos ONE 4(2):e4365, 2009 Pubmed

Hoffmann M, Rath E, Hölzlwimmer G, Loach D, Tannock G, Haller D. Lactobacillus reuteri 100-23 transiently activates intestinal epithelial cells of mice that have a complex microbiota during early stages of colonization. J. Nutr 138(9):1684-91, 2008 Pubmed

Shkoda A, Werner T, Daniel H, Gunckel M, Rogler G, Haller D. Differential protein expression profile in the intestinal epithelium from patients with inflammatory bowel disease. J Proteome Res 6(3):1114-25, 2007 Pubmed

Shkoda A, Ruiz PA, Daniel H, Kim SC, Rogler G, Sartor RB, Haller D. IL-10 blocked endoplasmatic reticulum stress in the intestinal epithelium: impact on chronic inflammation. Gastroenterology 132:190-207, 2007 Pubmed

Ruiz PA, Shkoda A, Kim SC, Sartor RB, Haller D. IL-10 gene deficient mice lack TGF-ß/Smad signaling and fail to inhibit pro-inflammatory gene expression in intestinal epithelial cells after the colonization with colitogenic Enterococcus faecalis. J Immunol 174:2990-2999, 2005 Pubmed




Laumen H, Saningong AD, Heid IM, Hess J, Herder C, Claussnitzer M, Baumert J, Lamina C, Rathmann W, Sedlmaier EM, Klopp N, Thorand B, Wichmann H-E, Illig T, Hauner H. Functional characterization of promotor variants of the adiponectin gene complemented by epidemiological data. Diabetes 2009, 58(4):984-91 Pubmed

Hauner H, Vollhardt Ch, Schneider KTM, Zimmermann A, Schuster T, Amann-Gassner U. The impact of nutritional fatty acids during pregnancy and lactation on early human adipose tissue development: rationale and design of the INFAT study. Ann Nutr Metab 2009;54:97-103 Pubmed

Laumen H, Skurk T, Hauner H. The HMG-CoA reductase inhibitor rosuvastatin inhibits plasminogen activator inhibitor-1 expression and secretion in human adipocytes. Atherosclerosis 2008; 196: 565-573 Pubmed

Lee Y, Skurk T, Hennig M, Hauner H. Effect of a milk drink supplemented with whey peptides on blood pressure in patients with mild hypertension. Eur J Nutr 2007; 46: 21-27 Pubmed

Skurk T , Alberti-Huber C, Herder C, Hauner H. Relationship between adipocyte size and adipokine expression and secretion. J Clin Endocrinol Metab 2007; 92: 1023-1033 Pubmed




Toelstede S, Hofmann T. Kokumi-active glutamyl peptides in cheeses and their biogeneration by Penicillium roquefortii. J Agric Food Chem 57:3738-3748, 2009 Pubmed

Lang R, Yagar EF, Eggers R, Hofmann T. Quantitative investigation of trigonelline, nicotinic acid, and nicotinamide in foods, urine, and plasma by means of LC-MS/MS and stable isotope dilution analysis. J Agric Food Chem 56:11114–11121, 2008 Pubmed

Stark T, Keller D, Wenker K, Hillmann H, Hofmann T. Nonenzymatic C-glycosylation of flavan-3-ols by oligo- and polysaccharides. J Agric Food Chem 55:9685–9697, 2007 Pubmed

Frank O, Zehentbauer G, Hofmann T. Bioresponse-guided decomposition of roast coffee beverage and identification of key bitter taste compounds. Eur Food Res Technol, 222:492-508, 2006

Bufe B, Hofmann T, Krautwurst D, Raguse J-D, Meyerhof W. The human T2R16 receptor mediates bitter taste in response to bitter ß-glycosides. Nature Genetics, 32:397-401, 2002




Fromme T, Hoffmann C, Nau K, Rozman J, Reichwald K, Utting M, Platzer M, Klingenspor M. An intronic single base exchange leads to a brown adipose tissue specific loss of Ucp3 expression and an altered body mass trajectory. Physiol Genomics (April 21, 2009). doi:10.1152/physiolgenomics.00249.2007 [Epub ahead of print] Pubmed

Jastroch M, Withers KW, Taudien S, Frappell PB, Helwig M, Fromme T, Hirschberg V, Heldmaier G, McAllan BM, Firth BT, Burmester T, Platzer M, Klingenspor M. Marsupial uncoupling protein 1 sheds light on the evolution of mammalian nonshivering thermogenesis. Physiol Genomics32(2):161-9, 2008. Pubmed

Meyer CW, Elvert R, Scherag A, Ehrhardt N, Gailus-Durner V, Fuchs H, Schafer H, Hrabe de AM, Heldmaier G, Klingenspor M. Power matters in closing the phenotyping gap. Naturwissenschaften94(5):401-6, 2007. Pubmed

Haemmerle G, Lass A, Zimmermann R, Gorkiewicz G, Meyer C, Rozman J, Heldmaier G, Maier R, Theussl C, Eder S, Kratky D, Wagner EF, Klingenspor M, Hoefler G, Zechner R. Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase. Science 312: 734-737, 2006 Pubmed

Kanzleiter T, Schneider T, Walter I, Bolze F, Eickhorst C, Heldmaier G, Klaus S, Klingenspor M. Evidence for NR4A1 as a cold-induced effector of brown fat thermogenesis. Physiol Genomics24(1):37-44, 2005 Pubmed




Yesil-Celiktas O, Otto F, Gruener S, Parlar H.Determination of extractability of pine bark using supercritical CO(2) extraction and different solvents: optimization and prediction. J Agric Food Chem.:57(2):341-7, 2009. PubMed

Fanous A, Weiss W, Görg A, Jacob F, Parlar H. A proteome analysis of the cadmium and mercury response in Corynebacterium glutamicum. Proteomics: 8(23-24):4976-86, 2008. PubMed

Nicolai A, Friess A, Parlar H Efficient enrichment of alpha,beta-unsaturated bovine insulins-(C12)n using tweezing adsorptive bubble separation (TABS) with bovine serum albumin. J Sep Sci:31(12):2310-7, 2008. PubMed

Ekici P, Friess A, Parlar H. Permissible level of toxaphene residues in fish from the German market based on in vivo and in vitro effects to tumor promotion. Food Chem Toxicol: 46(7):2320-5, 2008. PubMed

Raab U, Preiss U, Albrecht M, Shahin N, Parlar H, Fromme H. Concentrations of polybrominated diphenyl ethers, organochlorine compounds and nitro musks in mother's milk from Germany (Bavaria). Chemosphere: 72(1):87-94, 2008. PubMed

Fanous A, Weiland F, Lück C, Görg A, Friess A, Parlar H. A proteome analysis of Corynebacterium glutamicum after exposure to the herbicide 2,4-dichlorophenoxy acetic acid (2,4-D). Chemosphere: 69(1):25-31, 2007 PubMed




Huang F.-C., Horvath G, Molnar P, Turcsi E, Deli J, Schrader J, Sandmann G, Schmidt H, Schwab W. Substrate promiscuity of RdCCD1, a carotenoid cleavage oxygenase from Rosa damascena. Phytochemistry, 70, 457-464, 2009 PubMed

Schwab W, Davidovich-Rikanati R, Lewinsohn E. Biosynthesis of plant-derived flavor compounds. Plant J 54, 712-732, 2008 PubMed

Griesser M, Hoffmann T, Bellido ML, Rosati C, Fink B, Kurtzer R, Aharoni A, Munoz-Blanco J, Schwab W. Redirection of flavonoid biosynthesis through the downregulation of an anthocyanidin glucosyltransferase in ripening strawberry (Fragaria x ananassa) fruit, Plant Physiol 146, 1528-1539, 2008 PubMed

Landmann C, Fink B, Festner M, Dregus M, Engel KH, Schwab W. Cloning and functional characterization of three terpene synthases from lavender (Lavandula angustifolia), Arch Biochem Biophys 465, 417-429, 2007 PubMed

Hoffmann T, Kalinowski G, SchwabW. RNAi-induced silencing of gene expression in strawberry fruit (Fragaria x ananassa) by agroinfiltration: a rapid assay for gene function analysis. Plant J 48, 818-826, 2006 PubMed




Krueger D, Gruber L, Buhner S, Zeller F, Langer R, Seidl S, Michel K, Schemann M. The multi-herbal drug STW 5 (Iberogast(R)) has prosecretory action in the human intestine. Neurogastroenterol Motil Epub, 2009 PubMed

Schemann M, Rohn M, Michel K Motor control of the stomach. Eur Rev Med Pharmacol Sci. 12 Suppl 1:41-51, 2008 PubMed

Cellek S, Thangiah R, Bassil AK, Campbell CA, Gray KM, Stretton JL, Lalude O, Vivekanandan S, Wheeldon A, Winchester WJ, Sanger GJ, Schemann M, Lee K. Demonstration of functional neuronal beta3-adrenoceptors within the enteric nervous system. Gastroenterology 133:175-83, 2007 PubMed

Breunig E, Michel K, Zeller F, Seidl S, Weyhern CW, Schemann M. Histamine excites neurones in the human submucous plexus through activation of H1, H2, H3 and H4 receptors. J Physiol 583:731-42, 2007 PubMed

Schicho R, Krueger D, Zeller F, Von Weyhern CW, Frieling T, Kimura H, Ishii I, De Giorgio R, Campi B, Schemann M. Hydrogen sulfide is a novel prosecretory neuromodulator in the Guinea-pig and human colon. Gastroenterology 131:1542-52, 2006 PubMed




Fisher E, Boeing H, Fritsche A, Doering F, Joost HG ,Schulze MB. Whole-grain consumption and transcription factor-7-like 2 ( TCF7L2) rs7903146: gene-diet interaction in modulating type 2 diabetes risk. Br J Nutr 101:470-3, 2009 PubMed

Ford ES, Schulze MB, Bergmann MM, Thamer C, Joost HG ,Boeing H. Liver enzymes and incident diabetes: findings from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study. Diabetes Care 31:1138-43, 2008 PubMed

Heidemann C, Schulze MB, Franco OH, van Dam RM, Mantzoros CS, Hu FB. Dietary Patterns and Risk of Mortality From Cardiovascular Disease, Cancer, and All Causes in a Prospective Cohort of Women. Circulation 118:230-237, 2008 PubMed

Pischon T, Boeing H, Hoffmann K, Bergmann M, Schulze MB, Overvad K, van der Schouw YT, Spencer E, Moons KG, Tjønneland A, Halkjaer J, Jensen MK, Stegger J, Clavel-Chapelon F, Boutron-Ruault MC, Chajes V, Linseisen J, Kaaks R, Trichopoulou A, Trichopoulos D, Bamia C, Sieri S, Palli D, Tumino R, Vineis P, Panico S, Peeters PH, May AM, Bueno-de-Mesquita HB, van Duijnhoven FJ, Hallmans G, Weinehall L, Manjer J, Hedblad B, Lund E, Agudo A, Arriola L, Barricarte A, Navarro C, Martinez C, Quirós JR, Key T, Bingham S, Khaw KT, Boffetta P, Jenab M, Ferrari P, Riboli E. General and abdominal adiposity and risk of death in Europe. N Engl J Med 359:2105-20, 2008 PubMed

Stefan N, Fritsche A, Weikert C, Boeing H, Joost HG, Häring HU, Schulze MB. Plasma Fetuin-A Levels and the Risk of Type 2 Diabetes. Diabetes 57:2762-7, 2008 PubMed




Vogel RF, Ehrmann MA. Effects of pressure on lactic acid bacteria. In: High-Pressure Microbiology, Ed: Michiels, C, Bartlett, DH and Aertsen, A, 117-144, 2008

Behr J, Israel L, Gänzle MG, Vogel RF. A proteome approach for characterization of hop inducible proteins in Lactobacillus brevis. Appl Environ Microbiol 73:3300-6, 2007 PubMed

Hew CM, Korakli M, Vogel RF. Expression of virulence-related genes by Enterococcus faecalis in response to different environmemts. Syst Appl Microbiol 30:257-267, 2007 PubMed

Gänzle MG, Vermeulen N ,Vogel RF. Carbohydrate, peptide and lipid metabolism of lactic acid bacteria in sourdough. Food Microbiol 24:128-38,2007 PubMed

Jänsch A, Korakli M, Vogel RF, Gänzle MG. Glutathione reductase from Lactobacillus sanfranciscensis DSM20451T: contribution to oxygen tolerance and thiol exchange reactions in wheat sourdoughs. Appl Environ Microbiol 73:4469-76, 2007 PubMed